EDUCATION & MEDICAL TRAINING
1986 – MD – College of Physicians and Surgeons Columbia University – New York, NY, USA
1981 – BA (Oriental Studies), BAS (Computer Science) – University of Pennsylvania – Philadelphia, PA, USA
PATHOLOGY SPECIALTIES & INTERESTS
Liver Pathology, Stem cell research, Complexity theory, Consciousness studies, Human hepatocarcinogenesis
PEER REVIEWED PUBLICATIONS (selected from >150 total)
Theise ND, Saxena R, Portmann BP, Thung SN, Yee H, Chiriboga L Kumar A, Crawford JM. The canals of hering and hepatic stem cells in humans. Hepatology 1999; 30:1425-33 (featured on cover).
Theise ND, Badve S, Saxena R, Henegariu O, Sell S, Crawford JM, Krause DS. Derivation of Hepatocytes From Bone Marrow Cells in Mice After Radiation-Induced Myeloablation. Hepatology 2000; 31: 235-240 (featured on cover).
Theise ND, Nimmakayalu M, Gardner R, Illei P, Morgan G, Teperman L, Henegariu O, Krause DS. Liver from bone marrow in humans. Hepatology 2000; 32: 11-16. (Featured on cover; Selected as “most important contribution to Hepatology” in prior five year period by Editor in Chief E. Montgomery Bissell).
Krause DS*, Theise ND*, Collector MI, Henegariu O, Hwang S, Gardner R, Neutzel S, Sharkis SJ. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 2001; 105: 369-377. (*contributed equally)
Theise ND, Henegariu O, Grove J, Jagirdar J, Kao PN, Crawford JM, Badve S, Saxena R, Krause DS. Radiation pneumonitis in mice: A severe injury model for pneumocyte engraftment from bone marrow-derived cells. Exp Hematology 2002; 30: 1333-1338.
Theise ND, Krause DS. Bone marrow to liver: The blood of Prometheus. Semin Cell Dev Biol. 2002; 13: 411-7 [Invited review].
Theise ND, Krause DS, Sharkis S. Comments on: “Little evidence for stem cell plasticity.” Science 2003; 299: 1317.
Ianus IA, Holz GG, Theise ND, Hussain MA. In vivo derivation of glucose competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. JCI 2003; 111: 843-50 [Featured on cover].
Theise ND, Wilmut I. Cell plasticity: flexible arrangement. Nature 2003; 425: 21.
Falkowski O, An HJ, Ianus IA, Chiriboga L, Yee H, West AB, Theise ND. Regeneration of hepatocyte “buds” in cirrhosis from intrabiliary stem cells. J Hepatology 2003; 39: 357-364.
Theise ND. Liver stem cells: the fall and rise of tissue biology. Hepatology 2003; 38: 804-806.
Roskams TA*, Theise ND*, Balabaud C, Bhagat G, Bhathal PS, Bioulac-Sage P, Brunt EM, Crawford JM, Crosby HA, Desmet V, Finegold MJ, Geller SA, Gouw ASH, Hytiroglou P, Knisely AS, Kojiro M, Lefkowitch JH, Nakanuma Y, Olynyk JK, Park YN, Portmann B, Saxena R, Scheuer PJ, Strain AJ, Thung SN, Wanless IR, West AB. Nomenclature of the finer branches of the biliary tree: canals, ductules and ductular reactions in human livers. Hepatology 2004; 39: 1739-1745. [*contributed equally]
Kofman AV, Morgan G, Kirschenbaum A, Osbeck J, Hussain M, Swenson S, Theise ND. Dose- and time-dependent oval cell reaction in acetaminophen-induced murine liver injury. Hepatology 2005; 41: 1252-1261 [Highlighted on cover].
Theise ND. Cell doctrine: now you see it, now you don’t. Nature 2005; 435: 1165.
Theise ND, Harris R. Postmodern biology: (adult) (stem) cells are plastic, stochastic, complex, and uncertain. Handb Exp Pharmacol. 2006; 174: 389-408.
Theise ND. Gastrointestinal Stem Cells. III. Emergent themes of liver stem cell biology: niche, quiescence, self-renewal, and plasticity. Am J Physiol Gastrointest Liver Physiol. 2006; 290: G189-93.
Theise ND. Implications of ‘post-modern biology’ for pathology: the cell doctrine. Lab Invest 2006; 86: 335-44.
Park YN, Kojiro M, Di Tommaso L, Dhillon AP, Kondo F, Nakano M, Sakamoto M, Theise ND*, Roncalli M.* Ductular reaction is helpful in defining early stromal invasion, small hepatocellular carcinomas, and dysplastic nodules. Cancer 2007; 109: 915-23. (*co-Senior authors)
Theise ND. Liver biopsy assessment in chronic viral hepatitis: a personal, practical approach. Modern Pathol 2007: 20: S3-S14.
Cogle CR*, Theise ND*, Fu DT, Ucar D, Lee S, Guthrie SM, Lonergan J, Rybka W, Krause DS, Scott EW. Bone marrow contributes to epithelial cancers in mice and humans as developmental mimicry. Stem Cells 2007; 25: 1881–1887 (*co-first authors)
Theise ND. The stem cell niche and tissue biology. Stem Cell Reviews 2007; 2: 169-70.
Theise ND. The tissue biology of ductular reactions in chronic human liver disease. Gasteroenterology 2007; 133: 350-2. (Invited editorial).
Hytiroglou P, Park YN, Krinsky G, Theise ND. Hepatocarcinogenesis in humans: pathophysiology, radiographic detection and clinical significance. Gastroenterological Clinics of N.America. Gastroenterol Clin North Am. 2007; 36: 867-87.
Swenson ES, Kuwahara R, Krause DS, Theise ND. Physiological variations of stem cell factor and stromal-derived factor-1 in murine models of liver injury and regeneration. Liver International 2008; 308-318.
Kuwahara R, Kofman AV, Landis CS, Swenson ES, Barendswaard E, Theise ND. The hepatic stem cell niche: identification by label retaining cell assay. Hepatology 2008; 47:1994-2002 (featured on cover).
Zhang L*, Theise ND*, Chua M, Reid LM. The stem cell niche of human livers: symmetry between regeneration and development. Hepatology 2008; 48: 1598-607 (*contributed equally).
Swenson ES, Xanthopoulos J, Nottoli T, McGrath J, Theise ND, Krause DS. Chimeric mice reveal clonal development of pancreatic acini, but not islets. Biochem Biophys Res Commun 2009; 379: 526-31.
International Consensus Group for Hepatocellular Neoplasia (ICGHN) Group. Pathologic Diagnosis of Early Hepatocellular Carcinoma; A Report of the International Consensus Group for Hepatocellular Neoplasia. Hepatology 2009; 49: 658-64.
Nguyen C, Hudacko R, Theise ND, Tabaee A. Endoscopic management of cholesterol granuloma of the maxillary sinus. J Otolaryngol Head Neck Surg. 2009; 38: E69-72.
Bushell WC, Spector NH, Theise ND. From the global to the local: Possible pathways for the transduction of Indo-Sino-Tibetan cognitive-behavioral practices into site specific, tissue regenerative effects. Ann N Y Acad Sci. 2009; 1172: 74-87.
Theise ND. Beyond cell doctrine: complexity theory informs alternate models of the body for cross-cultural dialogue. Ann N Y Acad Sci. 2009; 1172: 263-9.
Bushell WC, Theise ND. Toward a unified field of study: longevity, regeneration, and protection of health through meditation and related practices. Ann N Y Acad Sci. 2009; 1172: 5-19.
Theise ND. Stem cell plasticity: recapping the decade, mapping the future. Exp Hematol 2010; 38: 529-39
Kuntsevich V, Bushell WC, Theise ND. Mechanisms of yogic practices in health, aging, and disease. Mt Sinai J Med 2010; 77: 559-69.
Yoon SM, Gerasimidou D, Kuwahara R, Hytiroglou P, Yoo JE, Park YN, Theise ND. Epithelial cell adhesion molecule (EpCAM) marks hepatocytes newly derived from stem/progenitor cells in humans. Hepatology. 2011; 53: 964-73.
Hudacko R, Theise ND. Chronic viral hepatitis: beyond grading and staging. Arch Pathol Lab Med. 2011; 135: 1320-8.
Gouw ASW, Clouston AD, Theise ND. Ductular reactions in human livers: diversity at the interface. Hepatology 2011; 54: 1853-63.
Hytiroglou P, Snover DC, Alves V, Balabaud C, Bhathal PS, Bioulac-Sage P, Crawford JM, Dhillon AP, Ferrell L, Guido M, Nakanuma Y, Paradis V, Quaglia A, Theise ND, Thung SN, Tsui WMS, van Leeuwen DJ. Beyond “cirrhosis”: a proposal from the international liver pathology study group. Amer J Clin Path 2012; 137: 5-9.
Brody RI, Theise ND. An inflammatory proposal for hepatocarcinogenesis. Hepatology 2012; 56: 382-4.
Khan F, Kamarla A, Mendoza P, Bodenheimer HC Jr, Theise ND. Keratin 19 demonstration of canal of Hering loss in primary biliary cirrhosis: “minimal change PBC”? Hepatology 2013; 57: 700-7.
Theise ND, Kafatos M. Sentience everywhere: complexity theory, panpsychism, and the role of sentience in the self organization of the universe. J Consciousness Exploration and Research 2013; 4: 378-90.
Theise ND, Dollé L, Kuwahara R. Low hepatocyte repopulation from stem cells: a matter of hepato-biliary linkage not massive production. Gastroenterology 2013 Gastroenterology. 2013 Jul;145(1):253-4.
Theise ND. Histopathology of alcoholic liver disease. Clinical Liver Disease 2013; 2: 64–67.
Theise ND, Kafatos M. Complementarity in biological systems. Complexity 2013; 18: 11–20 [Featured on the cover].
Michalopoulos GK, Grompe M, Theise ND. Assessing the potential of induced liver regeneration. Nat Med 2013; 19: 1096-7.
D’Inverno M, Theise ND, Prophet J. Mathematical modeling of stem cells: A complexity primer for the stem cell biologist. In: Potten C, Wilson J, Clarke R, Renahan A (eds.): Tissue stem cells: Biology and applications (2nd edition), Marcell Dekker Inc, New York NY, 2006.
Theise ND. Stem cell plasiticy: validation or valedictory? In: Meyer, U.; Meyer, Th.; Handschel, J.; Wiesmann, H.P. (Eds.) Fundamentals of Tissue Engineering and Regenerative Medicine. Springer. 2009.
Longevity and Optimal Health: Integrating Eastern and Western Perspectives. Bushell WC, Olivo EL, Theise ND, eds. Annals of the New York Academy of Medicine. New York NY USA. 2009.
Bosman F, Carneiro F, Hruban R, Theise ND, Eds. WHO Classification of Tumours of the Digestive System (4th edition). Geneva, Switzerland: WHO Press. 2010.
Theise ND, Bodenheimer H, Ferrell L. Viral hepatitis: In: Alastair D. Burt, Bernard C. Portmann, Linda D. Ferrell (eds.): MacSween’s Pathology of the Liver (6th edition). London UK: Saunders and Co. 2010.
Theise ND, Park Y-N. Hepatobiliary carcinoma. In: Saxena R. (ed.): Practical Hepatic Pathology: A Diagnostic Approach. Elsevier Inc, 2011.
Theise ND. Liver and Biliary Tree. In: Kumar V, Abbas AK, Mitchell R (eds.): Robbins’ Basic Pathology (9th edition). Elsevier Inc, 2011.
Theise ND. Liver and Gallbladder. In: Kumar V, Abbas AK, Aster Jon (eds) Robbins and Cotran Pathologic Basis of Disease (9th edition). Elsevier Inc, 2013 [In Press].
Theise ND. Liver Cancer. In: Stewart B, Wild CP, Eds. World Cancer Report 2013. Geneva, Switzerland: WHO Press. 2014.
Theise ND. Science as koan. Tricycle: The Buddhist Review. 2003; 12 (3): 81.
Theise ND. From the bottom up: Complexity, emergence and Buddhist metaphysics. Tricycle: The Buddhist Review. 2006; 15(2):24-26.
Chopra D, Hammeroff S, Kafatos MC, Tanzi RE, Theise ND. Dear TED, Is It ‘Bad Science’ or a ‘Game of Thrones’? The Huffington Post. Published on line April 18, 2013.
Chopra D, Doraiswamy M, Tanzi RE, Theise ND, Kafatos MC. Can reality set us free? The puzzle of complementarity. Parts 1, 2, 3. Simultaneously: San Francisco Chronicle and The Huffington Post. Published on line April 29, May 6, and May 20, 2013.
Chopra D, Doraiswamy M, Kafatos MC, Tanzi RE, Theise ND. Thinking outside the (skull) box. Parts1-7. Simultaneously: San Francisco Chronicle and The Huffington Post. Published on line August 12, , 20, 27 and Sept 4, 10, 17, 30, 2013. [lead author].
Chropra D, Kafatos M, Kak S, Tanzi RE, Theise ND. Can Brain Science Explain Experience? Parts 1-3. Simultaneously: San Francisco Chronicle and The Huffington Post. Published on line May 6, 13, 20, 2014.